Cyclooxygenase-2 expression in actinic keratosis

Cyclooxygenase in Cancer Prevention and Treatments for Actinic Keratosis

Non-steroidal anti-inflammatory drugs (NSAIDs) are a chemically diverse class of drugs that target the cyclooxygenase (COX) pathway and have anti-inflammatory, analgesic, and antipyretic properties. Elevated expression of COX-2 has been associated with tumor progression in skin cancer through multiple mechanisms. We present evidence for a chemoprotective effect of NSAIDs and discuss potential m...

Expression of Cyclooxygenase-2 and Ki-67 in Actinic Keratosis and Cutaneous Squamous Cell Carcinoma in Dogs

Actinic keratosis is a common disease in humans, which also affects dogs. Lesions occur in chronically sun exposed areas, such as flank, ventral and lateral abdomen. It has been reported that actinic keratosis is a pre-neoplastic disease which may evolve into squamous cell carcinoma (SCC), which is one of the most frequent malignant neoplasm in dogs. The aim of this research was to investigate ...

Sunlight (actinic) keratosis: an update.

L. FELLER, R.A.G. KHAMMISSA, N.H. WooD, Y. JADWAT, R. MEYERoV, J. LEMMER Department of Periodontology and oral Medicine, School of Dentistry, Faculty of Health Sciences, University of Limpopo, Medunsa Campus, South Africa; * School of Dentistry, Faculty of Health Sciences, University of Limpopo, Medunsa Campus, South Africa Professor Emeritus: University of Witwatersrand, Johannesburg, Universi...

Sebaceous carcinoma with actinic keratosis.

Actinic Keratosis: Rationale and Management

Actinic keratoses (AKs) are common skin lesions heralding an increased risk of developing squamous cell carcinoma (SCC) and other skin malignancies, arising principally due to excessive ultraviolet (UV) exposure. They are predominantly found in fair-skinned individuals, and increasingly, are a problem of the immunosuppressed. AKs may regress spontaneously, remain stable or transform to invasive...